Intensifying systemic therapy improves outcomes in metastatic prostate cancer. As apalutamide and enzalutamide join abiraterone and docetaxel as treatment options for patients, the choice of therapy for individual patients becomes more complex. We anticipate precision targeted and immune therapies will build on the advances of recently completed large-scale trials.
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T.M.B. has received research funding from Alliance Foundation Trials, Boehringer Ingelheim, Corcept Therapeutics, Endocyte Inc., Janssen Research & Development, Medivation, Inc./Astellas, OncoGenex, Sotio and Theraclone Sciences/OncoResponse, consulting fees from AbbVie, Astellas Pharma, AstraZeneca, Bayer, Boehringer Ingelheim, Clovis Oncology, GlaxoSmithKline, Janssen Biotech, Janssen Japan, Merck and Pfizer and owns stock in Salarius Pharmaceuticals. R.P.K. has received research funding from Merck and Roche.
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NCT01957436: https://clinicaltrials.gov/ct2/show/NCT01957436
NCT02799602: https://clinicaltrials.gov/ct2/show/NCT02799602
NCT03678025: https://clinicaltrials.gov/ct2/show/NCT03678025
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Kopp, R.P., Beer, T.M. Combining options in metastatic prostate cancer. Nat Rev Urol 16, 569–570 (2019). https://doi.org/10.1038/s41585-019-0217-z
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DOI: https://doi.org/10.1038/s41585-019-0217-z