Reassurance provided by pre-exposure prophylaxis (PrEP) for HIV might lead to increased sexual risk-taking in men who have sex with men (MSM), potentially increasing the risk of transmitting other infections. A recent study has shown increased transmission of hepatitis C virus (HCV) in this population, suggesting a need for HCV screening.
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References
Sewell, J. et al. Poly drug use, chemsex drug use, and associations with sexual risk behaviour in HIV-negative men who have sex with men attending sexual health clinics. Int. J. Drug Policy 43, 33–43 (2017).
Eaton, L. A. et al. Serosorting sexual partners and risk for HIV among men who have sex with men. Am. J. Prev. Med. 33, 479–485 (2007).
Bavinton, B. R. et al. Viral suppression and HIV transmission in serodiscordant male couples: an international, prospective, observational, cohort study. Lancet HIV 5, e438–e447 (2018).
Cohen, M. S. et al. Prevention of HIV-1 infection with early antiretroviral therapy. N. Engl. J. Med. 365, 493–505 (2011).
Marcus, J. L. et al. Redefining human immunodeficiency virus (HIV) preexposure prophylaxis failures. Clin. Infect. Dis. 65, 1768–1769 (2017).
Grant, R. M. et al. Preexposure chemoprophylaxis for HIV prevention in men who have sex with men. N. Engl. J. Med. 363, 2587–2599 (2010).
US Public Health Service. Preexposure prophylaxis for the prevention of HIV infection in the United States — 2017 update: a clinical practice guideline. Centers for Disease Control and Prevention https://www.cdc.gov/hiv/pdf/risk/prep/cdc-hiv-prep-guidelines-2017.pdf (2018).
Department of Health and Human Services Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the use of antiretroviral agents in adults and adolescents living with HIV. NIH https://aidsinfo.nih.gov/contentfiles/lvguidelines/AdultandAdolescentGL.pdf (2019).
Price, J. C. et al. Sexually acquired hepatitis C infection in HIV-uninfected men who have sex with men using preexposure prophylaxis against HIV. J. Infect. Dis. https://doi.org/10.1093/infdis/jiy670 (2018).
Centers for Disease Control and Prevention. Sexual transmission of hepatitis C virus among HIV-infected men who have sex with men — New York City, 2005–2010. MMWR Morb. Mortal. Wkly Rep. 60, 945–950 (2011).
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D.S.K. has been a consultant to Fenway Health for a study funded by Gilead Sciences and has received compensation for developing and/or delivering medical education related to PrEP for Medscape, MED-IQ and UptoDate, Inc. K.H.M. has conducted research with unrestricted project support from Gilead Sciences, Merck and ViiV Healthcare and has received compensation for developing medical education related to PrEP for UptoDate, Inc.
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Krakower, D.S., Mayer, K.H. Routine screening for hepatitis C in MSM on HIV PrEP. Nat Rev Urol 16, 272–274 (2019). https://doi.org/10.1038/s41585-019-0163-9
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DOI: https://doi.org/10.1038/s41585-019-0163-9
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