Year in Review | Published:

MICROBIOME IN 2018

Urobiome updates: advances in urinary microbiome research

Nature Reviews Urologyvolume 16pages7374 (2019) | Download Citation

Since the discovery and confirmation of the human urobiome, highly influential studies to characterize this microbial community and understand how it relates to human health and disease have been undertaken. Technological advances will improve information about the status of the urobiome for clinicians.

Key advances

  • Lactobacillus predominance does not differ between adult women with mixed urinary incontinence and age-matched asymptomatic women, but some members of the genus Lactobacillus might be associated with urinary symptoms5.

  • Preoperative assessment of the urinary microbiome could reduce bothersome urinary symptoms following surgery and reduce risk of perioperative urinary tract infection6.

  • Public databases are inadequate for studies of the urobiome and its relationship to bladder health and disease because these databases lack urobiome-specific genomes7.

  • Men with more severe urinary symptoms are more likely to have detectable bladder bacteria than those with less severe or no symptoms. Voided urine does not adequately characterize the male bladder urobiome, and catheterized urine should be used instead8.

  • The urobiome differs between individuals with bladder cancer and those without10.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    Mueller, E. R., Wolfe, A. J. & Brubaker, L. Female urinary microbiota. Curr. Opin. Urol. 27, 282–286 (2017).

  2. 2.

    Price, T. K. et al. The clinical urine culture: enhanced techniques improve detection of clinically relevant microorganisms. J. Clin. Microbiol. 54, 1216–1222 (2016).

  3. 3.

    Wolfe, A. J. et al. Evidence of uncultivated bacteria in the adult female bladder. J. Clin. Microbiol. 50, 1376–1383 (2012).

  4. 4.

    Lukacz, E. S. et al. A novel research definition of bladder health in women and girls: implications for research and public health promotion. J. Womens Health (Larchmt) 27, 974–981 (2018).

  5. 5.

    Komesu, Y. M. et al. The urinary microbiome in women with mixed urinary incontinence compared to similarly aged controls. Int. Urogynecol. J. https://doi.org/10.1007/s00192-018-3683-6 (2018).

  6. 6.

    Fok, C. S. et al. Urinary symptoms are associated with certain urinary microbes in urogynecologic surgical patients. Int. Urogynecol. J. https://doi.org/10.1007/s00192-018-3732-1 (2018).

  7. 7.

    Thomas-White, K. et al. Culturing of female bladder bacteria reveals an interconnected urogenital microbiota. Nat. Commun. 9, 1557 (2018).

  8. 8.

    Bajic, P. et al. Male bladder microbiome relates to lower urinary tract symptoms. Eur. Urol. Focus https://doi.org/10.1016/j.euf.2018.08.001 (2018).

  9. 9.

    Xu, W. et al. Mini-review: perspective of the microbiome in the pathogenesis of urothelial carcinoma. Am. J. Clin. Exp. Urol. 2, 57–61 (2014).

  10. 10.

    Popovic, V. B. et al. The urinary microbiome associated with bladder cancer. Sci. Rep. 8, 12157 (2018).

Download references

Acknowledgements

This work was supported by NIH grant 5R01DK104718-03 to A.J.W. and L.B.

Author information

Affiliations

  1. Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL, USA

    • Alan J. Wolfe
  2. Department of Obstetrics, Gynecology and Reproductive Sciences, Division of Female Pelvic Medicine and Reconstructive Surgery, University of California San Diego, La Jolla, CA, USA

    • Linda Brubaker

Authors

  1. Search for Alan J. Wolfe in:

  2. Search for Linda Brubaker in:

Competing interests

A.J.W. discloses Investigator Initiated Study funds from Astellas Scientific and Medical Affairs and Kimberly Clark Corporation. L.B. discloses editorial stipends from JAMA, Female Pelvic Medicine and Reconstructive Surgery and UpToDate.

Corresponding author

Correspondence to Alan J. Wolfe.

About this article

Publication history

Published

Issue Date

DOI

https://doi.org/10.1038/s41585-018-0127-5

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing