Penile carcinoma is a rare disease that is associated with substantial morbidity. Advances in cytotoxic chemotherapy have been disappointing in the first-line and salvage settings, but the association with human papillomavirus (HPV) infection and a tumour-site agnostic approach form the basis of ongoing clinical trials evaluating immunotherapy strategies.
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B.M. is a consultant for Bayer, Astellas, AstraZeneca, Seattle Genetics, Exelixis, Nektar, Pfizer, Janssen, and Genentech; and has received research support (institutional) from Bristol Myers Squibb (BMS) and speaker fees from Clinical Care Options and OncLive. G.S. is a consultant for Bayer, Sanofi, Pfizer, Novartis, Eisai, Janssen, Amgen, AstraZeneca, Merck, Genentech, Argos, EMD Serono and Agensys/Astellas; has received research support (institutional) from Bayer, Onyx, Celgene, Boehringer-Ingelheim, Merck, Pfizer, Sanofi, Janssen, AstraZeneca, and BMS; has received speaker fees from Clinical Care Options, Physicians Education Resource (PER), Research to Practice (RTP), and Onclive; and is an author for Uptodate.
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McGregor, B., Sonpavde, G. Immunotherapy for advanced penile cancer — rationale and potential. Nat Rev Urol 15, 721–723 (2018). https://doi.org/10.1038/s41585-018-0083-0
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DOI: https://doi.org/10.1038/s41585-018-0083-0
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