News & Views | Published:


Testosterone therapy and medical hysteria

Nature Reviews Urologyvolume 15pages659660 (2018) | Download Citation

A recent study has shown a decline in testosterone prescriptions since media reports of potential increased cardiovascular risk in 2014. The phenomenon of medical hysteria accounts for this reduced prescribing, as numerous subsequent studies provide substantial evidence of reduced cardiovascular risk and other important benefits with testosterone therapy for men with testosterone deficiency.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1.

    Traish, A. M., Vance, J. C. & Morgentaler, A. Overselling hysteria: the role of the media and medical journals in promoting questionable risks-a case study of the testosterone controversy. EMBO Rep. 18, 11–17 (2017).

  2. 2.

    Vigen, R. et al. Association of testosterone therapy with mortality, myocardial infarction, and stroke in men with low testosterone levels. JAMA 310, 1829–1836 (2013); erratum 311, 967 (2014).

  3. 3.

    Baillargeon, J. et al. Testosterone prescribing in the United States, 2002-2016. JAMA. 320, 200–202 (2018).

  4. 4.

    Morgentaler, A. et al. Testosterone therapy and cardiovascular risk: advances and controversies. Mayo Clin. Proc. 90, 224–251 (2015).

  5. 5.

    Traish, A. M., Guay, A. T. & Morgentaler, A. Death by testosterone? We think not! J. Sex. Med. 11, 624–629 (2014).

  6. 6.

    Morgentaler, A. & Lunenfeld, B. Testosterone and cardiovascular risk: world’s experts take unprecedented action to correct misinformation. Aging Male 17, 63–65 (2014).

  7. 7.

    Miner, M. et al. The state of testosterone therapy since the FDA’s 2015 labelling changes: indications and cardiovascular risk. Clin. Endocrinol. (Oxf.). 89, 3–10 (2018).

  8. 8.

    US Food and Drug Administration. (Accessed 6 March 2007).

  9. 9.

    Baillargeon, J. et al. Screening and monitoring in men prescribed testosterone therapy in the U. S., 2001–2010. Publ. Health Rep. 130, 143–152 (2015).

  10. 10.

    Morgentaler, A. et al. Fundamental concepts regarding testosterone deficiency and treatment: international expert consensus resolutions. Mayo Clin. Proc. 9, 881–896 (2016).

Download references

Author information


  1. Harvard Medical School, Boston, MA, USA

    • Abraham Morgentaler


  1. Search for Abraham Morgentaler in:

Competing interests

A.M. has received payments from Acerus for lecture honoraria, Aytu for consulting, and Endo for research grants.

Corresponding author

Correspondence to Abraham Morgentaler.

About this article

Publication history



Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing