Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Research Highlight
  • Published:

ALZHEIMER DISEASE

Reactive astrocyte biomarkers mirror Alzheimer disease pathology

Nature Reviews Neurology volume 18, page 575 (2022)Cite this article

Subjects

“We already know from transcriptomic studies that reactive astrocytes can acquire multiple molecular phenotypes in the brains of patients with AD,” explains lead author João Pedro Ferrari-Souza. “However, no previous study has demonstrated astrocyte heterogeneity in the living human brain, and we wanted to test whether we could use biomarkers of astrocyte reactivity to capture this phenomenon in AD.”

Ferrari-Souza and colleagues recruited 121 individuals aged 50 years or older from the Translational Biomarkers in Aging and Dementia (TRIAD) cohort, which is based at McGill University (Montreal, QC, Canada). The participants included 75 individuals without cognitive impairment, 29 individuals with mild cognitive impairment and 17 individuals with AD dementia.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

Original article

Related articles

  • Galea, E. et al. Multi-transcriptomic analysis points to early organelle dysfunction in human astrocytes in Alzheimer’s disease. Neurobiol. Dis. 166, 105655 (2022)

    Article  CAS  Google Scholar 

  • Jiwaji, Z. et al. Reactive astrocytes acquire neuroprotective as well as deleterious signatures in response to tau and Aβ pathology. Nat. Commun. 13, 135 (2022)

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Nature Reviews Neurology http://www.nature.com/nrneurol/

    Heather Wood

Authors
  1. Heather Wood
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Heather Wood.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wood, H. Reactive astrocyte biomarkers mirror Alzheimer disease pathology. Nat Rev Neurol 18, 575 (2022). https://doi.org/10.1038/s41582-022-00713-x

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41582-022-00713-x

Search

Advanced search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research