Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Research Highlight
  • Published:

ALZHEIMER DISEASE

Glutamate perpetuates amyloid-β-dependent neuronal hyperactivity

Nature Reviews Neurology volume 15, pages 558–559 (2019)Cite this article

Subjects

Amyloid-β (Aβ)-dependent neuronal hyperactivity is believed to be an early event in the pathogenesis of Alzheimer disease (AD) and has been implicated in the epileptic seizures that some individuals with this condition experience. As recently reported in Science, a research team led by Arthur Konnerth at the Technical University of Munich, Germany, has identified a role for impaired synaptic glutamate reuptake in perpetuating a ‘vicious cycle’ of Aβ-induced neuronal hyperactivation in the brain.

“We originally discovered neuronal hyperactivation in mouse models of AD, and since that time we have wondered about the underlying cellular and molecular mechanisms,” comments Konnerth. “As a first step, we found out that hyperactivity is mediated by soluble Aβ.”

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

Original article

  • Zott, B. et al. A vicious cycle of β amyloid-dependent neuronal hyperactivation. Science 365, 559–565 (2019)

    Article  CAS  Google Scholar 

Related articles

  • Busche, M. A. et al. Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer’s disease. Science 321, 1686–1689 (2008)

    Article  CAS  Google Scholar 

  • Busche, M. A. et al. Critical role of soluble amyloid-β for early hippocampal hyperactivity in a mouse model of Alzheimer’s disease. Proc. Natl Acad. Sci. USA 109, 8740–8745 (2012)

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Nature Reviews Neurology http://www.nature.com/nrneurol/

    Heather Wood

Authors
  1. Heather Wood
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Heather Wood.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wood, H. Glutamate perpetuates amyloid-β-dependent neuronal hyperactivity. Nat Rev Neurol 15, 558–559 (2019). https://doi.org/10.1038/s41582-019-0256-3

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41582-019-0256-3

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing