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PARKINSON DISEASE

White matter pathology predicts cognitive decline in PD

Nature Reviews Neurology volume 14, pages 690–691 (2018)Cite this article

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A large burden of white matter hyperintensities (WMHs) in the brain is predictive of accelerated cognitive decline in patients with de novo Parkinson disease (PD), according to a longitudinal study that was recently reported in NeuroImage: Clinical.

“Of the few studies that have investigated WMHs and cognitive decline in PD, most are cross-sectional, include patients that are on dopaminergic medication, and are typically from cohorts that are at later stages of disease,” the authors comment in their paper.

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References

Original article

  • Dadar, M. et al. White matter hyperintensities are linked to future cognitive decline in de novo Parkinson’s disease patients. Neuroimage Clin. 20, 892–900 (2018)

    Article  PubMed  PubMed Central  Google Scholar 

Further reading

  • Aarsland, D. et al. Cognitive decline in Parkinson disease. Nat. Rev. Neurol. 13, 217–231 (2017)

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  1. Nature Reviews Neurology http://www.nature.com/nrneurol/

    Heather Wood

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  1. Heather Wood
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Correspondence to Heather Wood.

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Wood, H. White matter pathology predicts cognitive decline in PD. Nat Rev Neurol 14, 690–691 (2018). https://doi.org/10.1038/s41582-018-0090-z

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  • DOI: https://doi.org/10.1038/s41582-018-0090-z

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