The drug development pipeline for kidney diseases is plagued with challenges ranging from an insufficient understanding of disease mechanisms to a lack of robust preclinical models. Bioengineering approaches have the potential to streamline preclinical drug discovery efforts and improve the success of clinical trials for kidney disease.
Access options
Subscribe to Journal
Get full journal access for 1 year
$209.00
only $17.42 per issue
All prices are NET prices.
VAT will be added later in the checkout.
Rent or Buy article
Get time limited or full article access on ReadCube.
from$8.99
All prices are NET prices.
References
- 1.
Chatzimanouil, M. K. T., Wilkens, L. & Anders, H.-J. Quantity and reporting quality of kidney research. J. Am. Soc. Nephrol. 30, 13–22 (2019).
- 2.
Ron, A. et al. Cell shape information is transduced through tension-independent mechanisms. Nat. Commun. 8, 2145 (2017).
- 3.
Soo, J. Y.-C., Jansen, J., Masereeuw, R. & Little, M. H. Advances in predictive in vitro models of drug-induced nephrotoxicity. Nat. Rev. Nephrol. 14, 378–393 (2018).
- 4.
Musah, S. et al. Mature induced-pluripotent-stem-cell-derived human podocytes reconstitute kidney glomerular-capillary-wall function on a chip. Nat. Biomed. Eng. 1, 0069 (2017).
- 5.
Weber, E. J. et al. Human kidney on a chip assessment of polymyxin antibiotic nephrotoxicity. JCI Insight 3, e123673 (2018).
- 6.
Homan, K. A. et al. Bioprinting of 3D convoluted renal proximal tubules on perfusable chips. Sci. Rep. 6, 34845 (2016).
- 7.
Takasato, M. et al. Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis. Nature 526, 564–568 (2015).
- 8.
Homan, K. A. et al. Flow-enhanced vascularization and maturation of kidney organoids in vitro. Nat. Methods 16, 255–262 (2019).
- 9.
Cruz, N. M. et al. Organoid cystogenesis reveals a critical role of microenvironment in human polycystic kidney disease. Nat. Mater. 16, 1112–1119 (2017).
- 10.
Hale, L. J. et al. 3D organoid-derived human glomeruli for personalised podocyte disease modelling and drug screening. Nat. Commun. 9, 5167 (2018).
Author information
Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Supplementary information
Rights and permissions
About this article
Cite this article
Anandakrishnan, N., Azeloglu, E.U. Kidney tissue engineering for precision medicine. Nat Rev Nephrol 16, 623–624 (2020). https://doi.org/10.1038/s41581-020-00355-6
Published:
Issue Date:
