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Kidney tissue engineering for precision medicine

The drug development pipeline for kidney diseases is plagued with challenges ranging from an insufficient understanding of disease mechanisms to a lack of robust preclinical models. Bioengineering approaches have the potential to streamline preclinical drug discovery efforts and improve the success of clinical trials for kidney disease.

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References

  1. Chatzimanouil, M. K. T., Wilkens, L. & Anders, H.-J. Quantity and reporting quality of kidney research. J. Am. Soc. Nephrol. 30, 13–22 (2019).

    Article  Google Scholar 

  2. Ron, A. et al. Cell shape information is transduced through tension-independent mechanisms. Nat. Commun. 8, 2145 (2017).

    Article  Google Scholar 

  3. Soo, J. Y.-C., Jansen, J., Masereeuw, R. & Little, M. H. Advances in predictive in vitro models of drug-induced nephrotoxicity. Nat. Rev. Nephrol. 14, 378–393 (2018).

    Article  CAS  Google Scholar 

  4. Musah, S. et al. Mature induced-pluripotent-stem-cell-derived human podocytes reconstitute kidney glomerular-capillary-wall function on a chip. Nat. Biomed. Eng. 1, 0069 (2017).

    Article  CAS  Google Scholar 

  5. Weber, E. J. et al. Human kidney on a chip assessment of polymyxin antibiotic nephrotoxicity. JCI Insight 3, e123673 (2018).

    Article  Google Scholar 

  6. Homan, K. A. et al. Bioprinting of 3D convoluted renal proximal tubules on perfusable chips. Sci. Rep. 6, 34845 (2016).

    Article  CAS  Google Scholar 

  7. Takasato, M. et al. Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis. Nature 526, 564–568 (2015).

    Article  CAS  Google Scholar 

  8. Homan, K. A. et al. Flow-enhanced vascularization and maturation of kidney organoids in vitro. Nat. Methods 16, 255–262 (2019).

    Article  CAS  Google Scholar 

  9. Cruz, N. M. et al. Organoid cystogenesis reveals a critical role of microenvironment in human polycystic kidney disease. Nat. Mater. 16, 1112–1119 (2017).

    Article  CAS  Google Scholar 

  10. Hale, L. J. et al. 3D organoid-derived human glomeruli for personalised podocyte disease modelling and drug screening. Nat. Commun. 9, 5167 (2018).

    Article  Google Scholar 

Download references

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Correspondence to Evren U. Azeloglu.

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Anandakrishnan, N., Azeloglu, E.U. Kidney tissue engineering for precision medicine. Nat Rev Nephrol 16, 623–624 (2020). https://doi.org/10.1038/s41581-020-00355-6

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