In the study of DNA modifications, the disciplines of epigenetics and of DNA damage and repair have evolved separately. The lines are now blurred by the realization that epigenetic modifications require DNA repair pathways for erasure and by the recent discoveries that oxidative DNA damage can upregulate gene expression.
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Research on this topic in our laboratory has been supported by the National Cancer Institute (R01 CA090689) and the National Institute of General Medical Sciences (R35 GM145237).
The authors declare no competing interests.
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Fleming, A.M., Burrows, C.J. DNA modifications walk a fine line between epigenetics and mutagenesis. Nat Rev Mol Cell Biol (2023). https://doi.org/10.1038/s41580-023-00590-2