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The lipotype hypothesis


Multicellular organisms consist of different cell types that emerge in response to instructive signals. New evidence suggests that lipid composition modulates cell response to signalling cues. Here we propose that cell variability in lipid composition assists the divergence of differentiation trajectories, leading to the establishment of several cell identities.

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Fig. 1: The lipotype hypothesis.


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We thank P. Gönczy for critically reading the manuscript.

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Correspondence to Giovanni D’Angelo or Gioele La Manno.

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The authors declare no competing interests.

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D’Angelo, G., La Manno, G. The lipotype hypothesis. Nat Rev Mol Cell Biol 24, 1–2 (2023).

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