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Lipids as the key to understanding α-synuclein behaviour in Parkinson disease

Parkinson disease is a devastating neurodegenerative condition that is characterized by intraneuronal toxic assemblies of the α-synuclein protein. In this Comment, we discuss the emerging role of lipids in understanding biology as well as in the identification of new therapeutic targets in this disease.

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Acknowledgements

We are grateful to the Azrieli Foundation for the award of an Azrieli Fellowship and Marguerite Stolz Research Fellowship.

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Correspondence to Avraham Ashkenazi.

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Stok, R., Ashkenazi, A. Lipids as the key to understanding α-synuclein behaviour in Parkinson disease. Nat Rev Mol Cell Biol 21, 357–358 (2020). https://doi.org/10.1038/s41580-020-0235-y

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