Biological information can be shared between cells via extracellular vesicles. However, how cargo carried by extracellular vesicles elicits biological responses remains unresolved. Deciphering the molecular mechanisms that govern packaging and targeted delivery of extracellular vesicle cargo will be required to establish extracellular vesicles as important signalling entities.
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Acknowledgements
The authors are grateful to members of the International Society for Extracellular Vesicles and all their colleagues for fruitful insights and for stimulating discussions. The authors thank the Fondation pour la Recherche Médicale (FRM), The Ligue National Contre le Cancer, Institut Curie and the Centre National de la Recherche Scientifique (CNRS) for support. This commentary is dedicated to the memory of our colleague Rose Johnstone for her pioneering studies.
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Raposo, G., Stahl, P.D. Extracellular vesicles: a new communication paradigm?. Nat Rev Mol Cell Biol 20, 509–510 (2019). https://doi.org/10.1038/s41580-019-0158-7
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DOI: https://doi.org/10.1038/s41580-019-0158-7
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