Ageing is the most important risk factor for the majority of human pathologies. We propose the concept that the advancement of the hallmarks of ageing is dictated by several distinct biological clocks that can be decelerated by the induction of autophagy. This ‘time dilation’ delays the time-dependent manifestation of multiple diseases.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Effects of acyl-coenzyme A binding protein (ACBP)/diazepam-binding inhibitor (DBI) on body mass index
Cell Death & Disease Open Access 09 June 2021
-
Mitochondrial health is enhanced in rats with higher vs. lower intrinsic exercise capacity and extended lifespan
npj Aging and Mechanisms of Disease Open Access 04 January 2021
-
Isobacachalcone induces autophagy and improves the outcome of immunogenic chemotherapy
Cell Death & Disease Open Access 26 November 2020
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$189.00 per year
only $15.75 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
López-Otín, C. et al. The hallmarks of aging. Cell 153, 1194–1217 (2013).
Kalfalah, F. et al. Crosstalk of clock gene expression and autophagy in ageing. Ageing 8, 1876–1895 (2016).
Madeo, F. et al. Caloric restriction mimetics against age-associated disease: targets, mechanisms, and therapeutic potential. Cell Metab. 29, 592–610 (2019).
Hansen, M., Rubinsztein, D. C. & Walker, D. W. Autophagy as a promoter of longevity: insights from model organisms. Nat. Rev. Mol. Cell Biol. 19, 579–593 (2018).
Levine, B. & Kroemer, G. Biological functions of autophagy genes: a disease perspective. Cell 176, 11–42 (2019).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
G.K. is a scientific cofounder for Samsara Therapeutics. The other author declares no conflict of interest.
Rights and permissions
About this article
Cite this article
Lopez-Otín, C., Kroemer, G. Decelerating ageing and biological clocks by autophagy. Nat Rev Mol Cell Biol 20, 385–386 (2019). https://doi.org/10.1038/s41580-019-0149-8
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41580-019-0149-8
This article is cited by
-
Mitochondrial health is enhanced in rats with higher vs. lower intrinsic exercise capacity and extended lifespan
npj Aging and Mechanisms of Disease (2021)
-
Effects of acyl-coenzyme A binding protein (ACBP)/diazepam-binding inhibitor (DBI) on body mass index
Cell Death & Disease (2021)
-
Acyl-CoA-binding protein (ACBP): a phylogenetically conserved appetite stimulator
Cell Death & Disease (2020)
-
Isobacachalcone induces autophagy and improves the outcome of immunogenic chemotherapy
Cell Death & Disease (2020)
-
Autophagy: a promising process for the treatment of acetaminophen-induced liver injury
Archives of Toxicology (2020)