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The challenges facing synthetic biology in eukaryotes

Synthetic biology is maturing into a true engineering discipline for model microorganisms, but remains far from straightforward for most eukaryotes. Here, we outline the key challenges facing those trying to engineer biology across eukaryota and suggest areas of focus that will aid future progress.

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For valuable input, we thank K. Polizzi, K. Haynes, D. Mehta, M. Elowitz and all those who voiced opinions on this subject on Twitter. F.C. is supported by the Imperial College London Junior Research Fellowship Scheme.

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Correspondence to Tom Ellis.

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Ceroni, F., Ellis, T. The challenges facing synthetic biology in eukaryotes. Nat Rev Mol Cell Biol 19, 481–482 (2018).

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