Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

An uneven race: genome editing for parasitic worms

This month’s Genome Watch highlights recent advances in genome editing of parasitic worms that affect one-fifth of humans globally.

Your institute does not have access to this article

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. Gang, S. S. et al. Targeted mutagenesis in a human-parasitic nematode. PLoS Pathog. 13, e1006675 (2017).

    Article  Google Scholar 

  2. Liu, C., Grote, A., Ghedin, E. & Unnasch, T. R. CRISPR-mediated transfection of Brugia malayi. PLoS Negl. Trop. Dis. 14, e0008627 (2020).

    CAS  Article  Google Scholar 

  3. Arunsan, P. et al. Programmed knockout mutation of liver fluke granulin attenuates virulence of infection-induced hepatobiliary morbidity. eLife 8, e41463 (2019).

    Article  Google Scholar 

  4. Ittiprasert, W. et al. Programmed genome editing of the omega-1 ribonuclease of the blood fluke, Schistosoma mansoni. eLife 8, e41337 (2019).

    Article  Google Scholar 

  5. Sankaranarayanan, G. et al. Large CRISPR-Cas-induced deletions in the oxamniquine resistance locus of the human parasite Schistosoma mansoni. Wellcome Open Res. 5, 178 (2021).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Gabriel Rinaldi.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Sankaranarayanan, G., Berriman, M. & Rinaldi, G. An uneven race: genome editing for parasitic worms. Nat Rev Microbiol 19, 621 (2021).

Download citation

  • Published:

  • Issue Date:

  • DOI:

Further reading


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing