Interdisciplinary strategies bridging oncology, neuroscience, bioelectronics and materials science will facilitate the development of next-generation therapies and devices for cancers of the central nervous system.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Mancusi, R. & Monje, M. The neuroscience of cancer. Nature 618, 467–479 (2023).
Venkatesh, H. S. et al. Electrical and synaptic integration of glioma into neural circuits. Nature 573, 539–545 (2019).
Krishna, S. et al. Glioblastoma remodelling of human neural circuits decreases survival. Nature https://doi.org/10.1038/s41586-023-06036-1 (2023).
Venkataramani, V. et al. Glutamatergic synaptic input to glioma cells drives brain tumour progression. Nature 573, 532–538 (2019).
Zeng, Q. et al. Synaptic proximity enables NMDAR signalling to promote brain metastasis. Nature 573, 526–531 (2019).
Taylor, K. R. et al. Glioma synapses recruit mechanisms of adaptive plasticity. Nature https://doi.org/10.1038/s41586-023-06678-1 (2023).
Guo, X. et al. Midkine activation of CD8+ T cells establishes a neuron–immune–cancer axis responsible for low-grade glioma growth. Nat. Commun. 11, 2177 (2020).
Buckingham, S. C. et al. Glutamate release by primary brain tumors induces epileptic activity. Nat. Med. 17, 1269–1274 (2011).
Campbell, S. L., Buckingham, S. C. & Sontheimer, H. Human glioma cells induce hyperexcitability in cortical networks. Epilepsia 53, 1360–1370 (2012).
Osswald, M. et al. Brain tumour cells interconnect to a functional and resistant network. Nature 528, 93–98 (2015).
Venkataramani, V. et al. Glioblastoma hijacks neuronal mechanisms for brain invasion. Cell 185, 2899–2917.e31 (2022).
Yu, K. et al. PIK3CA variants selectively initiate brain hyperactivity during gliomagenesis. Nature 578, 166–171 (2020).
Moses, M. A., Brem, H. & Langer, R. Advancing the field of drug delivery: taking aim at cancer. Cancer Cell 4, 337–341 (2003).
Vargason, A. M., Anselmo, A. C. & Mitragotri, S. The evolution of commercial drug delivery technologies. Nat. Biomed. Eng. 5, 951–967 (2021).
Tang, X., Shen, H., Zhao, S., Li, N. & Liu, J. Flexible brain–computer interfaces. Nat. Electron. https://doi.org/10.1038/s41928-022-00913-9 (2023).
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Competing interests
J.D.B. has an equity position in Treovir Inc. and UpFront Diagnostics. J.D.B. is also a co-founder of Centile Bioscience and on the NeuroX1 scientific advisory board. The other authors declare no competing interests. For a list of entities with which R.L. is or has been recently involved, compensated or uncompensated, see Supplementary Information.
Supplementary information
Rights and permissions
About this article
Cite this article
Bernstock, J.D., Johnston, B.R., Friedman, G.K. et al. Leveraging next-generation materials for cancer neuroscience therapies in the central nervous system. Nat Rev Mater (2024). https://doi.org/10.1038/s41578-024-00681-2
Published:
DOI: https://doi.org/10.1038/s41578-024-00681-2
