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IMMUNE REGULATION

TOX for tired T cells

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References

    Original article

    1. Scott, A. C. et al. TOX is a critical regulator of tumour-specific T cell differentiation. Nature https://doi.org/10.1038/s41586-019-1324-y (2019)

    2. Khan, O. et al. TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion. Nature https://doi.org/10.1038/s41586-019-1325-x (2019)

    3. Alfei, F. et al. TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection. Nature https://doi.org/10.1038/s41586-019-1326-9 (2019)

    4. Yao, C. et al. Single-cell RNA-seq reveals TOX as a key regulator of CD8+ T cell persistence in chronic infection. Nat. Immunol. 20, 890–901 (2019)

    5. Seo, H. et al. TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8+ T cell exhaustion. Proc. Natl Acad. Sci. USA 116, 12410–12415 (2019)

    6. Wang, X. et al. TOX promotes the exhaustion of antitumor CD8+ T cells by preventing PD1 degradation in hepatocellular carcinoma. J. Hepatol. https://doi.org/10.1016/j.jhep.2019.05.015 (2019)

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    Correspondence to Yvonne Bordon.

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