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Paroxysmal nocturnal haemoglobinuria

Paroxysmal nocturnal haemoglobinuria (PNH) is a rare haematological disease. A mutation in haematopoietic stem cells can result in the generation of red blood cells lacking surface molecules that prevent the complement system targeting the cells. This animation highlights the complex pathological mechanisms of PNH and the available treatments. To learn more about PNH, check out the Primer and PrimeView.

This animation from Nature Reviews Disease Primers is freely available online thanks to support from Alexion and Roche. This Nature Video is editorially independent. It is produced with third party financial support. Read more about Supported Content here:

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Paroxysmal nocturnal haemoglobinuria. Nat Rev Dis Primers 6, 15 (2020).

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