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Immunotherapy for glioblastoma: quo vadis?

Glioblastoma remains essentially incurable, and new therapeutic approaches are urgently needed. Now, the findings of three serial tissue-based studies suggest that immune-checkpoint inhibition can modify the glioblastoma microenvironment. Following these encouraging observations, the results of two phase III trials of immune-checkpoint inhibition in newly diagnosed glioblastoma, with larger cohorts of patients, are eagerly anticipated.

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Competing interests

M.W. has received research grants from Abbvie, Adastra, Dracen, Merck, Sharp & Dohme (MSD), Merck (EMD), Novocure, OGD2, Piqur and Roche and honoraria for lectures, participation in advisory boards and/or consultancy from Abbvie, Basilea, Bristol-Myers Squibb, Celgene, MSD, Merck (EMD), Novocure, Orbus, Roche and Tocagen. E.L.R. has received research grants Amgen, Mundipharma; honoraria for lectures or participation in advisory boards for Abbvie, Daiichi-Sankyo and Novartis.

Correspondence to Michael Weller.

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