Radiofrequency renal denervation (RF-RDN) inhibits the renin–angiotensin–aldosterone system and improves cardiovascular outcomes in a pig model of heart failure with reduced ejection fraction (HFrEF). Yucatan miniature pigs were subjected to 75 min of left anterior descending coronary artery balloon occlusion to induce a myocardial infarction, followed by 18 weeks of reperfusion. Animals with HFrEF (defined as a left ventricular (LV) ejection fraction <40%) were randomly assigned to receive bilateral RF-RDN (n = 10) or a sham procedure (n = 11) at 6 weeks after reperfusion. RF-RDN was associated with significant reductions in renal noradrenaline content, circulating angiotensin I and angiotensin II levels, LV end-systolic volume and LV fibrosis compared with controls. RF-RDN was also associated with significant increases in circulating B-type natriuretic peptide levels, LV longitudinal strain and LV ejection fraction. Moreover, RF-RDN improved coronary artery responses to vasodilators.
References
Original article
Sharp, T. E. III et al. Renal denervation prevents heart failure progression via inhibition of the renin-angiotensin system. J. Am. Coll. Cardiol. 72, 2609–2621 (2018)
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Lim, G.B. Benefits of renal denervation in HFrEF. Nat Rev Cardiol 16, 71 (2019). https://doi.org/10.1038/s41569-018-0139-0
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41569-018-0139-0