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Tumour metabolism

T cells feed into cancer immune escape

Nature Reviews Cancer volume 23, page 113 (2023)Cite this article

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Metabolic reprogramming in tumour cells is known to dampen antitumour immunity, however, whether immunosurveillance can guide tumour metabolism remained unexplored. Tsai et al. now show that interferon-γ (IFNγ), released during T cell-mediated immunosurveillance, drives MYC-dependent metabolic reprogramming in tumour cells to support their proliferation and immune escape.

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  1. Nature Reviews Cancer http://www.nature.com/nrc/

    Daniela Senft

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  1. Daniela Senft
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Correspondence to Daniela Senft.

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Senft, D. T cells feed into cancer immune escape. Nat Rev Cancer 23, 113 (2023). https://doi.org/10.1038/s41568-023-00550-0

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  • DOI: https://doi.org/10.1038/s41568-023-00550-0

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