Microscopic imaging in three dimensions enables numerous biological and clinical applications. However, high-resolution optical imaging preserved in a relatively large depth range is hampered by the rapid spread of tightly confined light due to diffraction. Here, we show that a particular disposition of light illumination and collection paths liberates optical imaging from the restrictions imposed by diffraction. This arrangement, realized by metasurfaces, decouples lateral resolution from the depth of focus by establishing a one-to-one correspondence (bijection) along a focal line between the incident and collected light. Implementing this approach in optical coherence tomography, we demonstrate tissue imaging at a wavelength of 1.3 µm with ~3.2 µm lateral resolution, maintained nearly intact over a 1.25 mm depth of focus, with no additional acquisition or computational burden. This method, termed bijective illumination collection imaging, is general and might be adapted across various existing imaging modalities.
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All data generated and analysed are included in the paper and its supplementary information. The imaging data presented in Fig. 6 are available at https://figshare.com/articles/figure/Fig_6e_TIF/17124062.
All custom codes or algorithms used to generate results that are reported in this manuscript are available from the corresponding authors upon reasonable request.
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This project was supported by funding from the Department of Defense under grant no. W81XWH2010300 awarded to H.P., the Natural Sciences and Engineering Research Council of Canada under grant no. 392075 awarded to M. Pahlevani and the National Institutes of Health under grant no. 5R01HL133664 and grant no. 1R01CA255326 awarded to M.J.S. This work was performed in part at Harvard’s Center for Nanoscale Systems (CNS), a member of the National Nanotechnology Coordinated Infrastructure (NNCI), supported by the National Science Foundation (NSF) under NSF award no. 1541959.
The authors declare no competing interests.
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Pahlevaninezhad, M., Huang, YW., Pahlevani, M. et al. Metasurface-based bijective illumination collection imaging provides high-resolution tomography in three dimensions. Nat. Photon. 16, 203–211 (2022). https://doi.org/10.1038/s41566-022-00956-6
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