Combination of physical tissue expansion and super-resolution radial fluctuations achieves nanoscale resolution in pathology specimens with LED-based widefield microscopy.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Kylies, D. et al. Nat. Nanotechnol. https://doi.org/10.1038/s41565-023-01328-z (2022).
Chen, F., Tillberg, P. & Boyden, E. Science 347, 54–548 (2015).
Wassie, A., Zhao, Y. & Boyden, E. Nat. Methods 16, 33–41 (2019).
Zhao, Y. et al. Nat. Biotechnol. 35, 757–764 (2017).
Gustafsson, M. et al. Nat. Commun. 7, 12471 (2016).
Glaser, A. K. et al. Nat. Biomed. Engin. 1, 0084 (2017).
Liu, J. T. C. et al. Nat. Biomed. Engin. 5, 203–218 (2021).
Laine, R. F. et al. Preprint at bioRxiv https://doi.org/10.1101/2022.04.07.487490 (2022).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
Y.Z. and B.R.G. are inventors of several inventions related to ExM.
Rights and permissions
About this article
Cite this article
Gallagher, B.R., Zhao, Y. Imaging pathology goes nanoscale with a low-cost strategy. Nat. Nanotechnol. 18, 324–325 (2023). https://doi.org/10.1038/s41565-023-01318-1
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41565-023-01318-1