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Cancer immunotherapy

Improving treatment of solid cancers by nanoconjugate-mediated immune conversion of tumour cells

A strategy that uses nanoconjugates to label solid cancer cells with the hematopoietic cell-specific molecule SLAMF7, broadens the scope of cancer types susceptible to immune-based anti-cancer therapies and could provide a new approach to treat solid cancers.

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Fig. 1: Nanoconjugates to broaden the scope of solid tumour cells susceptible to macrophage-based immunotherapy.

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Correspondence to André Veillette.

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Competing interests

A.V. received a contract from Bristol Myers Squibb to study the mechanism of action of anti-SLAMF7 antibody elotuzumab in multiple myeloma. He also consulted for Boehringer Ingelheim on SIRPα-CD47 blockade. The other author declares no competing interests.

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Tang, Z., Veillette, A. Improving treatment of solid cancers by nanoconjugate-mediated immune conversion of tumour cells. Nat. Nanotechnol. (2022). https://doi.org/10.1038/s41565-022-01244-8

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  • DOI: https://doi.org/10.1038/s41565-022-01244-8

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