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Rebound virus in the cerebrospinal fluid reveals a possible HIV-1 reservoir

Rebound virus in the cerebrospinal fluid revealed viral lineages selected for growth in T cells that were clonally amplified and often distinct from the majority of rebound viral lineages in the blood.

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Fig. 1: Viral populations in the blood and CSF before therapy and after therapy interruption.

References

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This is a summary of: Kincer, L. P. et al. Rebound HIV-1 in cerebrospinal fluid after antiviral therapy interruption is mainly clonally amplified R5 T cell-tropic virus. Nat. Microbiol. https://doi.org/10.1038/s41564-022-01306-6 (2023).

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Rebound virus in the cerebrospinal fluid reveals a possible HIV-1 reservoir. Nat Microbiol 8, 195–196 (2023). https://doi.org/10.1038/s41564-022-01309-3

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