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Uncovering the role of the airway microbiome in chronic obstructive pulmonary disease

Now, a study using multi-omics to investigate the mechanistic role of the airway microbiome in chronic obstructive pulmonary disease (COPD) reveals that the airway microbiome-derived metabolite indole-3-acetic acid (IAA) can alleviate COPD-associated airway inflammation and epithelial apoptosis. These results implicate IAA as a potential therapeutic candidate for further investigation in COPD.

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Fig. 1: The top microbiome–host interaction links in neutrophilic COPD.

References

  1. Barnes, P. J. Inflammatory endotypes in COPD. Allergy 74, 1249–1256 (2019). A review article describing the inflammatory endotypes of COPD.

    PubMed  Google Scholar 

  2. Wang, Z. et al. Inflammatory endotype-associated airway microbiome in chronic obstructive pulmonary disease clinical stability and exacerbations: a multicohort longitudinal analysis. Am. J. Respir. Crit. Care Med. 203, 1488–1502 (2021). This paper reports the association of the airway microbiome with COPD endotypes and inflammation.

    Article  CAS  Google Scholar 

  3. Budden, K. F. et al. Functional effects of the microbiota in chronic respiratory disease. Lancet Respir. Med. 7, 907–920 (2019). A review article that presents the current knowledge regarding the functional roles of the airway microbiome.

    Article  Google Scholar 

  4. Yadava, K. et al. Microbiota promotes chronic pulmonary inflammation by enhancing IL-17A and autoantibodies. Am. J. Respir. Crit. Care Med. 193, 975–987 (2016). This paper reports a murine model for emphysema and airway inflammation that is used in our study.

    Article  CAS  Google Scholar 

  5. Carney, S. M. et al. Methods in lung microbiome research. Am. J. Respir. Cell Mol. Biol. 62, 283–299 (2021). A review article that presents current methods in lung microbiome research.

    Article  Google Scholar 

Download references

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This is a summary of: Yan, Z. et al. Multi-omics analyses of airway host–microbe interactions in chronic obstructive pulmonary disease identify potential therapeutic interventions. Nat. Microbiol. https://doi.org/10.1038/s41564-022-01196-8 (2022).

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Uncovering the role of the airway microbiome in chronic obstructive pulmonary disease. Nat Microbiol 7, 1333–1334 (2022). https://doi.org/10.1038/s41564-022-01202-z

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