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Uncovering the role of the airway microbiome in chronic obstructive pulmonary disease

Now, a study using multi-omics to investigate the mechanistic role of the airway microbiome in chronic obstructive pulmonary disease (COPD) reveals that the airway microbiome-derived metabolite indole-3-acetic acid (IAA) can alleviate COPD-associated airway inflammation and epithelial apoptosis. These results implicate IAA as a potential therapeutic candidate for further investigation in COPD.

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Fig. 1: The top microbiome–host interaction links in neutrophilic COPD.


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This is a summary of: Yan, Z. et al. Multi-omics analyses of airway host–microbe interactions in chronic obstructive pulmonary disease identify potential therapeutic interventions. Nat. Microbiol. (2022).

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Uncovering the role of the airway microbiome in chronic obstructive pulmonary disease. Nat Microbiol 7, 1333–1334 (2022).

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