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VIRAL ASSEMBLY

The TRiCky business of reovirus assembly

Nature Microbiology volume 3, pages 400–401 (2018)Cite this article

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The TRiC chaperonin has been identified as a crucial player in the assembly of reovirus capsids by folding the σ3 outer-capsid protein into its native conformation. These findings provide a functional understanding of TRiC in virus replication and a rationale for the development of TRiC inhibitors as broad-spectrum anti-viral agents.

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Fig. 1: Reovirus σ3 protein requires the TRiC chaperonin for folding into native conformers.

References

  1. Cherry, S. Curr. Opin. Microbiol. 12, 446–452 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Knowlton, J. J. et al. Nat. Microbiol. https://doi.org/10.1038/s41564-018-0122-x (2018).

    PubMed  Google Scholar 

  3. Lopez, D., Dalton, K. & Frydman, J. J. Mol. Biol. 427, 2919–2930 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Lingappa, J. R. et al. J. Cell. Biol. 125, 99–111 (1994).

    Article  CAS  PubMed  Google Scholar 

  5. Hong, S. et al. J. Virol. 75, 2526–2534 (2001).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Hafirassou, M. L. et al. Cell. Rep. 21, 3900–3913 (2017).

    Article  CAS  PubMed  Google Scholar 

  7. Inoue, Y. et al. Virology 410, 38–47 (2011).

    Article  CAS  PubMed  Google Scholar 

  8. Fislova, T., Thomas, B., Graef, K. M. & Fodor, E. J. Virol. 84, 8691–8699 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Zhang, J. et al. J. Virol. 87, 7608–7621 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Schmechel, S. et al. Virology 232, 62–73 (1997).

    Article  CAS  PubMed  Google Scholar 

  11. Bassiouni, R. et al. Clin. Cancer Res. 22, 4366–4379 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Carr, A. C. et al. Oncotarget. 8, 110273–110288 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Veterinary Microbiology and Preventive Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA, USA

    Cathy L. Miller

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  1. Cathy L. Miller
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Correspondence to Cathy L. Miller.

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The author declares no competing interests.

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Miller, C.L. The TRiCky business of reovirus assembly. Nat Microbiol 3, 400–401 (2018). https://doi.org/10.1038/s41564-018-0137-3

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