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Cancer migration

Unjamming tumour cell invasion through cGAS–STING

Nature Materials volume 22, pages 532–533 (2023)Cite this article

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Locally confined epithelial malignancies undergo a phase transition from a solid-like to liquid-like state, a process called unjamming, where associated chronic intracellular strain causes nuclear envelope rupture, leading to the emergence of pro-metastatic traits due to cGAS–STING pathway activation.

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Fig. 1: Phase transition from solid- to fluid-like invokes a cytosolic DNA response.

References

  1. Giavazzi, F. et al. J. Phys. D 50, 384003 (2017).

    Article  Google Scholar 

  2. Lanzetti, L., Palamidessi, A., Areces, L., Scita, G. & Di Fiore, P. P. Nature 429, 309–314 (2004).

    Article  CAS  Google Scholar 

  3. Frittoli, E. et al. Nat. Mater. https://doi.org/10.1038/s41563-022-01431-x (2022).

    Article  Google Scholar 

  4. Harada, T. et al. J. Cell Biol. 204, 669–682 (2014).

    Article  CAS  Google Scholar 

  5. Bakhoum, S. et al. Nature 553, 467–472 (2018).

    Article  CAS  Google Scholar 

  6. Patel, S. A., Rodrigues, P., Wesolowski, L. & Vanharanta, S. Br. J. Cancer 124, 3–12 (2021).

    Article  CAS  Google Scholar 

  7. Nguyen, B. et al. Cell 185, 563–575.e11 (2022).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Physiology and Biophysics and Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA

    Matthew Deyell

  2. Human Oncology and Pathogenesis Program and Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Samuel F. Bakhoum

Authors
  1. Matthew Deyell
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  2. Samuel F. Bakhoum
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Corresponding authors

Correspondence to Matthew Deyell or Samuel F. Bakhoum.

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Competing interests

S.F.B. has patents related to targeting chromosomal instability and cGAS–STING signalling in cancer. He also owns equity in, receives compensation from, serves as a consultant to, and is on the Scientific Advisory Board and Board of Directors of, Volastra Therapeutics Inc. M.D. declares no competing interests.

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Deyell, M., Bakhoum, S.F. Unjamming tumour cell invasion through cGAS–STING. Nat. Mater. 22, 532–533 (2023). https://doi.org/10.1038/s41563-023-01542-z

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