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Reply to: Towards increasing the clinical applicability of machine learning biomarkers in psychiatry

Nature Human Behaviour volume 5, pages 433–435 (2021)Cite this article

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The Original Article was published on 05 April 2021

replying to J. Dukart et al. Nature Human Behaviour https://doi.org/10.1038/s41562-021-01086-9 (2021)

We thank Dukart et al.1 for their commentary, and for the opportunity to clarify several points in our paper2. Although we agree with the need for caution in interpreting small studies, we nevertheless uphold the importance of early reports of novel approaches that are couched in cautious language and that acknowledge the limitations of a small sample, as our paper did.

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Fig. 1: Distribution of classification accuracies obtained with random permutations of group membership labels.
Fig. 2: Discriminating locations produced by varying the number of voxels included from each participant.

Data availability

No new data are used in this response; all data are available in the original publication upon reasonable request from the corresponding author.

Code availability

The custom computer code that was used in the main analysis of this study is available at https://doi.org/10.5281/zenodo.4549106.

References

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Author information

Authors and Affiliations

  1. Department of Psychology, Carnegie Mellon University, Pittsburgh, PA, USA

    Marcel Adam Just & Vladimir L. Cherkassky

  2. Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

    David Brent

Authors
  1. Marcel Adam Just
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  2. Vladimir L. Cherkassky
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  3. David Brent
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Contributions

The data were analysed by M.A.J. and V.L.C. The paper was written by M.A.J., V.L.C. and D.B.

Corresponding author

Correspondence to Marcel Adam Just.

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The authors declare no competing interests.

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Peer review information Nature Human Behaviour thanks Barry Horwitz and the other, anonymous, reviewer(s) for their contribution to the peer review of this work.

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Supplementary Information

Supplementary Discussion, Supplementary Fig. 1 and Supplementary References.

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Just, M.A., Cherkassky, V.L. & Brent, D. Reply to: Towards increasing the clinical applicability of machine learning biomarkers in psychiatry. Nat Hum Behav 5, 433–435 (2021). https://doi.org/10.1038/s41562-021-01086-9

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