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Native iron reduces CO2 to intermediates and end-products of the acetyl-CoA pathway

Nature Ecology & Evolutionvolume 2pages10191024 (2018) | Download Citation

Abstract

Autotrophic theories for the origin of life propose that CO2 was the carbon source for primordial biosynthesis. Among the six known CO2 fixation pathways in nature, the acetyl-CoA (AcCoA; or Wood–Ljungdahl) pathway is the most ancient, and relies on transition metals for catalysis. Modern microbes that use the AcCoA pathway typically fix CO2 with electrons from H2, which requires complex flavin-based electron bifurcation. This presents a paradox: how could primitive metabolic systems have fixed CO2 before the origin of proteins? Here, we show that native transition metals (Fe0, Ni0 and Co0) selectively reduce CO2 to acetate and pyruvate—the intermediates and end-products of the AcCoA pathway—in near millimolar concentrations in water over hours to days using 1–40 bar CO2 and at temperatures from 30 to 100 °C. Geochemical CO2 fixation from native metals could have supplied critical C2 and C3 metabolites before the emergence of enzymes.

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Acknowledgements

This project has received funding from the European Research Council under the European Union’s Horizon 2020 research and innovation programme (grant agreement 639170). Further funding was provided by a grant from LabEx ‘Chemistry of Complex Systems’. L. Allouche, M. Coppe and B. Vincent are gratefully acknowledged for assistance with the NMR experiments. We thank E. Smith and W. F. Martin for critical readings of this manuscript.

Author information

Author notes

  1. These authors contributed equally: Sreejith J. Varma and Kamila B. Muchowska.

Affiliations

  1. Institute of Supramolecular Science and Engineering (UMR 7006), University of Strasbourg, National Center for Scientific Research , Strasbourg, France

    • Sreejith J. Varma
    • , Kamila B. Muchowska
    • , Paul Chatelain
    •  & Joseph Moran

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Contributions

J.M. supervised the research and the other authors performed the experiments. All authors contributed intellectually throughout the study. J.M. and K.B.M wrote the paper, and S.J.V. and K.B.M. assembled the Supplementary Information. Important preliminary experiments were carried out by P.C.

Competing interests

The authors declare no competing interests.

Corresponding author

Correspondence to Joseph Moran.

Supplementary information

  1. Supplementary Information

    Supplementary Methods, Supplementary Figures 1–35, Supplementary Tables 1–19

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DOI

https://doi.org/10.1038/s41559-018-0542-2

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