Interactions between proteins and non-proteinaceous biopolymers are essential for life; however, many methods used to characterize these interactions lack precision and display significant biases. Now, a genetically encoded method employing sulfur(vi) fluoride exchange (SuFEx)-based chemical crosslinking has been developed for capturing and analysing protein–RNA and protein–carbohydrate interactions in vivo.
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Watkins, C.P., Flynn, R.A. A (cross)link in the chains. Nat. Chem. 15, 5–6 (2023). https://doi.org/10.1038/s41557-022-01116-7
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DOI: https://doi.org/10.1038/s41557-022-01116-7