Aryl aminooxetanes are used as amide bioisosteres in drug discovery but there are limited strategies for synthesizing them. Now, an approach has been developed that simplifies the synthesis of these privileged motifs, enabling a broad range of amines to be used.
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Huestis, M.P., Terrett, J.A. Simple strategy towards amide bioisosteres. Nat. Chem. 14, 120–121 (2022). https://doi.org/10.1038/s41557-021-00874-0
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DOI: https://doi.org/10.1038/s41557-021-00874-0
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