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Mild map to quinone methides

The widespread application of quinone methides — reactive intermediates in a variety of reactions — is limited by their tedious synthesis. Now, hypoiodite catalysis allows the efficient generation and use of these species in a plethora of tandem processes for the functionalization and synthesis of biologically active compounds.

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Fig. 1: A mild oxidative generation of QMs via hypoiodite catalysis.

Adapted with permission from ref. 4, Springer Nature Ltd.


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Correspondence to Boris J. Nachtsheim.

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Nachtsheim, B.J. Mild map to quinone methides. Nat. Chem. 12, 326–328 (2020).

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