Deciphering bacterial signalling

Bacterial communication is a potential strategy to control bacterial behaviours and thus, attenuate pathogen infectivity; however, identifying the signalling molecules that regulate communication pathways is challenging. Now, a robust strategy to rapidly identify previously unknown signalling peptides has been developed. This approach provides a means to map out and decipher bacterial signalling mechanisms.

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Fig. 1: Native chemical ligation-driven identification of thiolactone-containing peptides.


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Correspondence to Yftah Tal-Gan.

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McBrayer, D.N., Tal-Gan, Y. Deciphering bacterial signalling. Nat. Chem. 11, 398–399 (2019).

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