Compound 21
1-(4-iodophenyl)piperidine
From: Practical and regioselective amination of arenes using alkyl amines
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Synthetic procedure: See article for the definitive version of this procedure and for full experimental details.
Following GP1 outlined for compound 4, in 1,1,1,3,3,3-hexafluoro-i-propanol (HFIP), iodobenzene (23 µL, 0.2 mmol) gave 21 (25 mg, 85%) as a solid. 1H NMR (400 MHz, CDCl3) δ 7.47 (2H, m), 6.69 (2H, m), 3.09 (4H, m), 1.70-1.63 (4H, m), 1.57-1.51 (2H, m); 13C NMR (101 MHz, CDCl3) δ 151.9, 137.9, 118.6, 80.8, 50.4, 25.8, 24.4.
