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Metabolism

EPAC1 boosts thermogenic adipocyte formation

Nature Cell Biology volume 26, pages 39–40 (2024)Cite this article

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β-adrenergic signalling induces thermogenesis in mature brown adipocytes through a well-known cAMP–protein kinase A (PKA) pathway and also promotes the growth and differentiation of new thermogenic adipocytes. A study now demonstrates that β-adrenergic agonists drive this pathway through a PKA-independent mechanism involving cAMP–EPAC1.

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Fig. 1: Sympathetic stimulation induces brown fat activation and differentiation through PKA-dependent and PKA-independent pathways, respectively.

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  1. Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA, USA

    Evan D. Rosen

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  1. Evan D. Rosen
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Correspondence to Evan D. Rosen.

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E.D.R. consults for Novartis and is on the Advisory Board of Source Bio.

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Rosen, E.D. EPAC1 boosts thermogenic adipocyte formation. Nat Cell Biol 26, 39–40 (2024). https://doi.org/10.1038/s41556-023-01304-8

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