Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Cancer

Metabolically regulated lineages in prostate cancer

Nature Cell Biology volume 25, pages 1726–1728 (2023)Cite this article

Subjects

Lineage plasticity and epigenetic changes underlie prostate development and cancer evolution. A new study shows that basal and luminal prostate cells have distinct metabolic profiles, with a basal-to-luminal shift intensifying pyruvate oxidation. Metabolic changes in turn influence chromatin architecture, lineage reprogramming and treatment sensitivity.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Interplay between metabolism and the epigenome in prostate cancer.

References

  1. Zong, Y. et al. Proc. Natl Acad. Sci. USA 109, E3395–E3404 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Beltran, H. et al. Nat. Med. 22, 298–305 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Bakht, M. K. et al. Nat. Cancer 4, 699–715 (2023).

    Article  CAS  PubMed  Google Scholar 

  4. Zadra, G. & Loda, M. Cold Spring Harb. Perspect. Med. 8, a030569 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Jadvar, H. J. Nucl. Med. 57, 25s–29s (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Bakht, M. K. et al. J. Nucl. Med. 61, 904–910 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Buteau, J. P. et al. Lancet Oncol. 23, 1389–1397 (2022).

    Article  CAS  PubMed  Google Scholar 

  8. Butler, L. M. et al. Cancer Res. 81, 4981–4993 (2021).

    Article  CAS  PubMed  Google Scholar 

  9. Mishra, R. et al. J. Clin. Invest. 128, 4472–4484 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  10. Reina-Campos, M. et al. Cancer Cell 35, 385–400.e389 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Yang, Q. et al. Cell Metab. 24, 542–554 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Giafaglione, J. M. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-023-01274-x (2023).

    Article  PubMed  Google Scholar 

  13. Latham, T. et al. Nucleic Acids Res. 40, 4794–4803 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Lu, X. et al. Nat. Genet. 54, 670–683 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Davis, M. I., Bennett, M. J., Thomas, L. M. & Bjorkman, P. J. Proc. Natl Acad. Sci. USA 102, 5981–5986 (2005).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA

    Martin K. Bakht & Himisha Beltran

  2. Harvard Medical School, Boston, MA, USA

    Martin K. Bakht & Himisha Beltran

Authors
  1. Martin K. Bakht
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Himisha Beltran
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Himisha Beltran.

Ethics declarations

Competing interests

H.B. has served as a consultant/advisory board member for Janssen, Astellas, Astra Zeneca, Merck, Pfizer, Foundation Medicine, Amgen, Bayer, Oncorus, LOXO, Daicchi Sankyo and Curie Therapeutics (for work unrelated to the present study). H.B.’s institution has received research funding from Janssen, AbbVie/Stemcentrx, Eli Lilly, Astellas, Millennium, Bristol Myers Squibb, Circle Pharma, Daicchi Sankyo and Novartis (for work unrelated to the present study). M.K.B. declares no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Bakht, M.K., Beltran, H. Metabolically regulated lineages in prostate cancer. Nat Cell Biol 25, 1726–1728 (2023). https://doi.org/10.1038/s41556-023-01298-3

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41556-023-01298-3

Search

Advanced search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer