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Organelles

Dissecting organelle interdependence

Nature Cell Biology volume 26, pages 31–33 (2024)Cite this article

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The structures and functions of organelles are highly interdependent. Using paired 3D electron microscopy and multi-omics, a study now shows how other organelles affect mitochondrial structure and function: peroxisome-derived lipids reverse mitochondrial stress, highlighting the importance of organelle interconnectivity.

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Fig. 1: The dynamic organellar interconnectome.

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Acknowledgements

Funding was provided by the UNCF/Bristol-Myers Squibb E.E. Just Faculty Fund, Career Award at the Scientific Interface (CASI award) from the Burroughs Welcome Fund (BWF) 1021868.01, a BWF ad-hoc award, National Institutes of Health (NIH) Small Research Pilot Subaward 5R25HL106365-12 from the NIH PRIDE Program, DK020593, the Vanderbilt Diabetes and Research Training Center for DRTC Alzheimer’s Disease Pilot & Feasibility Program, CZI Science Diversity Leadership grant 2022-253529 from the Chan Zuckerberg Initiative DAF, and an advised fund of the Silicon Valley Community Foundation. The content is solely the responsibility of the authors and does not represent the official views of the National Institutes of Health.

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  1. Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA

    Antentor Hinton Jr. & Andrea G. Marshall

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  1. Antentor Hinton Jr.
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  2. Andrea G. Marshall
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Correspondence to Antentor Hinton Jr..

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Hinton, A., Marshall, A.G. Dissecting organelle interdependence. Nat Cell Biol 26, 31–33 (2024). https://doi.org/10.1038/s41556-023-01285-8

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