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Extracellular vesicles, genetic programmers

Extracellular vesicles carry proteins and lipids between cells. In a giant step forward for the field, a 2007 study published in Nature Cell Biology showed that secreted vesicles contain genetic material that is active within acceptor cells, reviving interest in extracellular vesicle-based communication in plant and animal biology.

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Fig. 1: EV-mediated exchange of genetic material.

References

  1. Pan, B. T. et al. J. Cell Biol. 101, 942–948 (1985).

    Article  CAS  PubMed  Google Scholar 

  2. Harding, C. et al. J. Cell Biol. 97, 329–339 (1983).

    Article  CAS  PubMed  Google Scholar 

  3. Raposo, G. et al. J. Exp. Med. 183, (1996).

  4. Hoshino, A. et al. Cell 182, 1044–1061.e18 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Valadi, H. et al. Nat. Cell Biol. 9, 654–659 (2007).

    Article  CAS  PubMed  Google Scholar 

  6. Ratajczak, J. et al. Leukemia 20, 847–856 (2006).

    Article  CAS  PubMed  Google Scholar 

  7. Nolte-’t Hoen, E. N. M. et al. Nucleic Acids Res. 40, 9272–9285 (2012).

    Article  PubMed  PubMed Central  Google Scholar 

  8. O’Brien, K. et al. Nat. Rev. Mol. Cell Biol. 21, 585–606 (2020).

    Article  PubMed  PubMed Central  Google Scholar 

  9. Villarroya-Beltri, C. et al. Nat. Commun. 4, 2980 (2013).

    Article  PubMed  Google Scholar 

  10. Ma, L. et al. eLife 12, e85878 (2023).

    Article  PubMed  PubMed Central  Google Scholar 

  11. Barman, B. et al. Dev. Cell 57, 974–994.e8 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Nederveen, J. P. et al. Front. Physiol. 11, 604274 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  13. Ying, W. et al. Cell Metab. 33, 781–790.e5 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Cai, Q. et al. Extracell. Vesicles Circ. Nucleic Acids 4, 262–282 (2023).

    Article  CAS  Google Scholar 

  15. Pita, T. et al. Int. J. Mech. Sci. 21, 9634 (2020).

    CAS  Google Scholar 

Download references

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Correspondence to Graça Raposo.

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Raposo, G., Stahl, P.D. Extracellular vesicles, genetic programmers. Nat Cell Biol 26, 22–23 (2024). https://doi.org/10.1038/s41556-023-01277-8

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