There is increasing interest in approaches that target and eliminate senescent cells. A study reports that the coatomer complex I (COPI) pathway is important for the survival of senescent cells, and suggests that targeting this pathway could hold therapeutic promise in the context of senescence-associated diseases.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Gorgoulis, V. et al. Cell 179, 813–827 (2019).
Schafer, M. J. et al. Nat. Commun. 8, 14532 (2017).
Ogrodnik, M. et al. Nat. Commun. 8, 15691 (2017).
Schmitt, C. A., Wang, B. & Demaria, M. Nat. Rev. Clin. Oncol. 19, 619–636 (2022).
McHugh, D. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-023-01287-6 (2023).
Beck, R., Ravet, M., Wieland, F. T. & Cassel, D. FEBS Lett. 583, 2701–2709 (2009).
Taylor, R. J., Tagiltsev, G. & Briggs, J. A. G. FEBS Lett. 597, 819–835 (2023).
Claude, A. et al. J Cell Biol 146, 71–84 (1999).
Phillips, L. R., Supko, J. G. & Malspeis, L. Anal Biochem. 211, 16–22 (1993).
Beauchamp, E. et al. Nat. Commun. 11, 5348 (2020).
Priyamvada, L. et al. PLoS Pathog. 18, e1010662 (2022).
Yuan, M. et al. Acta Pharmacol. Sin. 41, 1005–1015 (2020).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Victorelli, S., Passos, J.F. COPIng with senescence. Nat Cell Biol 25, 1724–1725 (2023). https://doi.org/10.1038/s41556-023-01276-9
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41556-023-01276-9
