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RNA modification

O-GlcNAc regulates YTHDF1 and YTHDF3 activity

Nature Cell Biology volume 25, pages 1570–1572 (2023)Cite this article

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YTHDF family members are ‘readers’ of a common mRNA modification, but their effects on mRNA translation and stability have been disputed. A new study shows that YTHDF1 and YTHDF3 are post-translationally regulated through O-GlcNAcylation, unifying disparate results and pointing to environmental cues that could modulate YTHDF function.

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Fig. 1: O-GlcNAcylation regulates YTHDF1/3 function.

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Acknowledgements

We thank Y. Nam for comments on the manuscript.

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Authors and Affiliations

  1. Department of Biochemistry, UT Southwestern, Dallas, TX, USA

    Mary W. N. Burns & Jennifer J. Kohler

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  1. Mary W. N. Burns
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  2. Jennifer J. Kohler
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Correspondence to Jennifer J. Kohler.

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The authors declare no competing interests.

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Burns, M.W.N., Kohler, J.J. O-GlcNAc regulates YTHDF1 and YTHDF3 activity. Nat Cell Biol 25, 1570–1572 (2023). https://doi.org/10.1038/s41556-023-01275-w

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