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Nuclear organization

Keeping membraneless organelles apart

Nature Cell Biology volume 25, pages 1566–1567 (2023)Cite this article

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How spatial organization in the cell is achieved on the organelle scale is unclear. A new study finds that tethering specific proteins near the surface of micelle-like paraspeckles modifies their properties and determines whether these subnuclear organelles are separate from, adhere to, or are engulfed by nuclear speckles.

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Fig. 1: Nuclear MLOs have a specific, multilayered substructural organization.

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Authors and Affiliations

  1. Department of Physics, Kansas State University, Manhattan, KS, USA

    Jeremy D. Schmit

  2. Center for Cancer Cell Biology, Rosalind Franklin University of Medicine & Science, Chicago Medical School, North Chicago, IL, USA

    Miroslav Dundr

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  1. Jeremy D. Schmit
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  2. Miroslav Dundr
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Correspondence to Miroslav Dundr.

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The authors declare no competing interests

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Schmit, J.D., Dundr, M. Keeping membraneless organelles apart. Nat Cell Biol 25, 1566–1567 (2023). https://doi.org/10.1038/s41556-023-01265-y

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