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Phase separation

Saving ribosomal proteins for later

Nature Cell Biology volume 25, pages 1568–1569 (2023)Cite this article

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Disruption of ribosome assembly results in the accumulation of aggregation-prone ‘orphaned’ ribosomal proteins that are toxic to cells if left unchecked. A study finds that cells store such ribosomal proteins during heat shock to enable a quick recovery of ribosome assembly after the removal of this stress.

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Fig. 1: Chaperones store orphaned ribosomal proteins at the nucleolar periphery during heat shock stress.

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Authors and Affiliations

  1. Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Joshua J. Black & Rachel Green

  2. Howard Hughes Medical Institute, Chevy Chase, MD, USA

    Joshua J. Black & Rachel Green

Authors
  1. Joshua J. Black
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  2. Rachel Green
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Correspondence to Rachel Green.

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Competing interests

R.G. is a member of the scientific advisory board of Alltrna, Initial Therapeutics and Arrakis Pharmaceuticals and serves as a consultant to Vertex Pharmaceuticals, Brystol-Myers Squibb (Celgene), Monta Rosa Therapeutics and Flagship Pioneering. R.G. previously served on the scientific advisory board at Moderna. J.J.B. declares no competing interests.

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Black, J.J., Green, R. Saving ribosomal proteins for later. Nat Cell Biol 25, 1568–1569 (2023). https://doi.org/10.1038/s41556-023-01251-4

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