Epithelial–mesenchymal transition (EMT) is crucial in embryogenesis and can be exploited by cancer cells to gain metastatic abilities. A hallmark of EMT is E-cadherin loss. In 2000, Snail was reported as the first E-cadherin repressor identified in the context of EMT, advancing our understanding of embryonic development and cancer progression.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Cano, A. et al. Nat. Cell Biol. 2, 76–83 (2000).
Batlle, E. et al. Nat. Cell Biol. 2, 84–89 (2000).
Thiery, J. P. et al. Cell 139, 871–890 (2009).
Yang, J. & Weinberg, R. A. Dev. Cell. 14, 818–829 (2008).
Tsai, J. H. et al. Cancer Cell 22, 725–736 (2012).
Dongre, A. & Weinberg, R. A. Nat. Rev. Mol. Cell Biol. 20, 69–84 (2019).
Kalluri, R. & Weinberg, R. A. J. Clin. Invest. 119, 1420–1428 (2009).
Greenburg, G. & Hay, E. D. J. Cell. Biol. 95, 333–339 (1982).
Comijn, J. et al. Mol. Cell. 7, 1267–1278 (2001).
Yang, J. et al. Cell 117, 927–939 (2004).
Eger, A. et al. Oncogene 24, 2375–2385 (2005).
Debnath, P. et al. Biosci. Rep. 42, BSR20211754 (2022).
Ma, L. et al. Nat. Cell Biol. 12, 247–256 (2010).
Fischer, K. R. et al. Nature 527, 472–476 (2015).
Zheng, X. et al. Nature 527, 525–530 (2015).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Sun, Y., Ma, L. A milestone in epithelial–mesenchymal transition. Nat Cell Biol 26, 29–30 (2024). https://doi.org/10.1038/s41556-023-01228-3
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41556-023-01228-3
