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Epigenetics

A non-coding m6A reader promotes leukaemia

Nature Cell Biology volume 25, pages 1247–1249 (2023)Cite this article

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Pathways linked to the modification of RNA with N6-methyladenosine (m6A) are known to be involved in initiating and maintaining cancer. But many of the key components of these pathways remain undiscovered. The RBFOX2 protein has now been identified as an m6A reader involved in locus-specific chromatin regulation, with therapeutic implications for myeloid leukaemia.

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Fig. 1: Binding of RBFOX2 to m6A-modified caRNAs regulates gene expression in myeloid leukaemia.

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Authors and Affiliations

  1. Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK

    James Russell & Konstantinos Tzelepis

  2. Department of Haematology, University of Cambridge, Cambridge, UK

    James Russell & Konstantinos Tzelepis

  3. Milner Therapeutics Institute, University of Cambridge, Cambridge, UK

    Konstantinos Tzelepis

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  1. James Russell
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  2. Konstantinos Tzelepis
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Correspondence to Konstantinos Tzelepis.

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Russell, J., Tzelepis, K. A non-coding m6A reader promotes leukaemia. Nat Cell Biol 25, 1247–1249 (2023). https://doi.org/10.1038/s41556-023-01205-w

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