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Reprogramming

Chemical fast track to induced pluripotency

Nature Cell Biology volume 25, pages 1079–1080 (2023)Cite this article

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A fast protocol for chemical cellular reprogramming reveals a diapause-like state, endogenous retrovirus activation and barriers to cell-fate transitions on the way to pluripotency. The system offers insights into manipulation of cellular regeneration and rejuvenation, two processes with great therapeutic potential.

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Fig. 1: Cellular reprogramming protocols produce transient cell states with potential for regenerative medicine.

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Authors and Affiliations

  1. Altos Labs, Inc, San Diego, CA, USA

    Sebastian Memczak & Juan Carlos Izpisua Belmonte

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  1. Sebastian Memczak
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  2. Juan Carlos Izpisua Belmonte
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Correspondence to Juan Carlos Izpisua Belmonte.

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The authors are employees of Altos Labs.

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Memczak, S., Izpisua Belmonte, J.C. Chemical fast track to induced pluripotency. Nat Cell Biol 25, 1079–1080 (2023). https://doi.org/10.1038/s41556-023-01202-z

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