Pioneer transcription factors bind closed chromatin regions, alter local accessibility and activate target genes. A study reveals that the SOX9 transcription factor drives cell fate switching by activating hair follicle cell enhancers, while simultaneously repressing epidermal enhancers via sequestration of epigenetic factors.
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Yi, R., Dou, Y. Pioneer factor competing for fate change. Nat Cell Biol 25, 1081–1082 (2023). https://doi.org/10.1038/s41556-023-01190-0
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DOI: https://doi.org/10.1038/s41556-023-01190-0
