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DNA replication

Transient chromatin compaction in fork restart

Nature Cell Biology volume 25, pages 931–932 (2023)Cite this article

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The compact state of chromatin induced by the methylation of lysine 9 on histone H3 has long been implicated in a heritable state of transcriptional repression. A study now shows that transient deposition of H3K9me3 helps to stabilize stalled DNA replication forks, while its reversal enables accurate fork restart.

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Fig. 1: A replication fork challenged by hydroxyurea or other replication stress.

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Authors and Affiliations

  1. ISREC Foundation, Agora Cancer Research Center, Lausanne, Switzerland

    Susan M. Gasser

  2. University of Lausanne, Department of Fundamental Microbiology, Lausanne, Switzerland

    Susan M. Gasser

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  1. Susan M. Gasser
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Correspondence to Susan M. Gasser.

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The author has no competing interests.

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Gasser, S.M. Transient chromatin compaction in fork restart. Nat Cell Biol 25, 931–932 (2023). https://doi.org/10.1038/s41556-023-01181-1

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