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o8G modifications rewire tumoral microRNAs

Nature Cell Biology volume 25, pages 1243–1244 (2023)Cite this article

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An Author Correction to this article was published on 18 September 2023

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RNA modifications have emerged as key gene regulators. A new study shows that increased levels of reactive oxygen species in cancer induce widespread, sequence-specific modifications of guanines in the seed regions of microRNAs, altering the targets of those miRNAs and influencing tumorigenesis.

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Fig. 1: Modification of o8G regulates miRNA function to redirect networks in cancer.

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Authors and Affiliations

  1. DNA and RNA Medicine Division, Center for Applied Medical Research, University of Navarra, Pamplona, Spain

    Marta Montes & Maite Huarte

  2. Instituto de Investigación Sanitaria de Navarra (IdISNA), Cancer Center Clínica Universidad de Navarra (CCUN), Pamplona, Spain

    Marta Montes & Maite Huarte

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  1. Marta Montes
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  2. Maite Huarte
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Correspondence to Maite Huarte.

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Montes, M., Huarte, M. o8G modifications rewire tumoral microRNAs. Nat Cell Biol 25, 1243–1244 (2023). https://doi.org/10.1038/s41556-023-01179-9

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